WebA STAT3 palmitoylation cycle promotes TH17 differentiation and colitis. Abstract: 2024: 1: 33033368: Yeliseev A et al. Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture. Abstract: 2024: 1: 32986127: Sharma C et al. WebOct 8, 2024 · It helps STAT3 go to the plasma membrane, where JAK2 is located, by applying a fatty acid, or lipid, to the protein. The lipid’s greasiness directs STAT3 to the …
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WebAbstract. The pleiotropic pro-inflammatory cytokine tumour necrosis factor alpha (TNF) is synthesised as a transmembrane protein that is subject to palmitoylation. In this study, the roles of this acylation on TNF-mediated biological effects were investigated. We found that the lipid raft partitioning of TNF is regulated by its palmitoylation. WebOct 20, 2024 · STAT3 palmitoylation by DHHC7 enhanced its phosphorylation and activation by JAK2. Although acyl protein thioesterases (APTs) remove palmitoyl groups … how do you pronounce audacity
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WebHere we show that STAT3 is post-translationally S-palmitoylated at the SRC homology 2 (SH2) domain, which promotes the dimerization and transcriptional activation of STAT3. … WebNov 1, 2024 · STAT3 is the primary substrate for DHHC5 palmitoylation in oligodendrocytes. Zdhhc5 ablation reduces STAT3 palmitoylation and suppresses STAT3 phosphorylation and activation. As a result, the transcription of the myelin-related and anti-apoptosis genes is inhibited, leading to suppressed oligodendrocyte development and … WebJun 17, 2024 · Besides, palmitoylation is involved in microglia proliferation and neuroinflammation . A recent study showed that a palmitoylation cycle modulated the activation and nucleus translocation of STAT3 in response to inflammation . The palmitoylation cycle is regulated by DHHC7 and APT2. how do you pronounce authentication