Cisplatin pubmed

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WebMar 2, 2024 · Weekly Cisplatin Plus Radiation for Postoperative Head and Neck Cancer … WebIntroduction: The aim of this multicenter phase II trial was to evaluate the combination of oral vinorelbine and cisplatin with radiotherapy (RT) after cisplatin-docetaxel induction chemotherapy (CT) in patients with locally advanced non-small cell lung cancer (NSCLC). Patients and methods: Patients with previously untreated, inoperable, histologically or …

Population pharmacokinetics of cisplatin in small cell lung …

WebCisplatin induces apoptosis of A549 cells by downregulating peroxidase V Cisplatin treatment induces the ROS production, increases the apoptotic rate and downregulates the Prx expression in A549 cells. Cisplatin treatment induces the ROS production, increases the apoptotic rate and downregulates the Prx expression in A549 cells. WebDec 1, 2024 · Methods. In this open-label, randomized, phase III study, newly diagnosed patients with advanced NSCLC were initially randomized (R1, 1:1) to receive first-line treatment with cisplatin 75 mg/m 2 plus docetaxel 75 mg/m 2 (DC75) or 60 mg/m 2 (DC60) for up to 4 cycles. Patients without progression were further randomized (R2, 1:2) to best … sylvain caba safti

Cisplatin treatment of primary and metastatic epithelial

WebCisplatin (Platinol) has an important dose-response relationship in ovarian cancer. We … WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and contraindications for cisplatinum as a valuable agent in treating malignancy. WebKidney injury molecule-1 (KIM-1) is a novel biomarker promising the diagnosis of AKI in early stages. We studied whether urinary and serum KIM-1 (KIM-1 U and KIM-1 S ) concentrations were useful in predicting cisplatin-induced AKI in early stages. Methods: We prospectively analysed 22 patients on cisplatin treatment. sylvain cadars

Cisplatin pubmed

WebGemcitabine and cisplatin plus durvalumab are being evaluated in the phase 3, TOPAZ … WebJun 21, 2024 · This trial compared cisplatin with cisplatin plus delayed administration of …

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WebIntroduction: Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the … WebCisplatin is a highly effective antitumor drug generally used in the treatment of solid …

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also …

WebCisplatin is one of the most widely used antineoplastic agents in the treatment of solid tumour and haematological malignancies, including cancers of the testes, ovary, bladder, head and neck, oesophagus, stomach and lung, as well as lymphoma and osteosarcoma. WebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc.

WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), w …

WebFerroptosis had great potential to become a new approach in anti-tumor therapies and make up for some classic drugs, which open up a new way for their utility in clinic. Keywords: Cisplatin; Erastin; Ferroptosis; Glutathione; Glutathione … tfnsw statement of business ethicsWebCisplatin-resistant bladder cancer overexpresses particular sugar chains compared with chemotherapy-naïve bladder cancer. Using a recombinant protein from the malaria parasite Plasmodium falciparum, we can target these sugar chains, and our results showed a significant antitumor effect in cisplatin- … sylvain campeauWebThirty-eight patients (33%) experienced grade 3 or 4 cisplatin related toxicities with 15 patients (12%) requiring significant dose modification. The reduced dose intensity in Study 99.06 improved tolerability. Incidence of significant late morbidity was low (6%). sylvain cabaretWebAug 8, 2010 · Cisplatin is one of the most effective anticancer agents widely used in the … tfnsw strategic cycleway corridorWebJul 1, 2024 · Background/aim: Cisplatin combined with pemetrexed disodium heptahydrate (pemetrexed) is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer. However, its growth-inhibitory effects on KRAS-dependent lung cancer as monotherapy and combination therapy are not well understood. sylvain cadotWebWe demonstrate that cisplatin-induced transition from epithelial to mesenchymal … tfnsw state road mapWebThe platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladd … sylvain cachard